Association of British Clinical Diabetologists

Exenatide QW Nationwide Audit

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Exenatide (Exendin-4) is the synthetic version of a salivary protein found in the Gila monster (shown above). It has approximately 50% identity with human GLP-1, it binds to known human GLP-1 receptors on beta cells in vitro, and is resistant to DPP-IV inactivation


Above: Gradual dissolution of the microspheres provides a steady release of exenatide  – click to enlarge


Above: At 30 weeks exenatide QW significantly improved HbA1c reductions compared to twice daily exenatide - click to enlarge


Above: The most common adverse events with exenatide QW were nausea, diarrhoea, injection-site pruritus, and vomiting. Nausea and vomiting occurred less frequently with exenatide QW compared to the twice daily preparation - click to enlarge


Above: Compared to the weight gain associated with use of insulin glargine, exenatide QW was associated with weight loss. But to what extent will this be reflected in real clinical use? - click to enlarge

ABCD nationwide exenatide QW audit on N3

About the ABCD nationwide exenatide QW audit
This is the latest of ABCD’s GLP-1 receptor agonist audits, following in the wake of the original ABCD nationwide exenatide audit, and the still on-going ABCD nationwide liraglutide audit. The great step forward for this audit is that it is being hosted on N3 - the latest version of NHSnet. Access the on-line tool for the audit does require the user to be on N3 – ie in an NHS hospital, GP surgery etc. The audit launched in April 2014 and has a number of objectives.

The new web-based audit tool on N3
The new audit tool is based on the liraglutide audit tool. It is easy to use. Being on N3 it has optimum security for patient identifiable data with regard to your own patients, but anonymises the data when it is sent to the national audit. There are some enhancements with regard to the data export both for your own local analysis and for the nationwide analysis. The export now allows you to choose which data to download for analysis as well as providing all data. It also allows you to choose to download the data aggregated to 2 monthly, 3 monthly, 4 monthly or 6 monthly time points.  The tool has the facility to detect data from the same patient entered in two sites (eg hospital and primary care) and to merge the data when exported - see centres and sites below.

Structure of the audit – centres and sites
For this audit the concept of centres and sites is developed more than previously in our audits. Typically a centre might be an NHS Trust. Sites might be hospitals associated with that Trust, and/or health centres or GP surgeries in the local vicinity. If set up in this structure, designated leaders of the local audit would be given access to download the anonymised data of all the patients associated with the centre for more powerful local analysis of data involving higher numbers. Findings so made through such local analysis could be put forward for further testing on the full national dataset.

Collect data on-line or via paper forms
The new N3 on-line audit tool is so easy to use that live data entry in clinic is a real option to be considered. Otherwise to facilitate data collection during clinics there are two paper forms which exactly match the data that can be entered into the audit tool. You can download and print these forms locally or
order pre-printed data entry forms.

To download the forms to printout for use, use the following links:

Download first visit data entry form
Download follow up visit data entry form

Non ABCD members
Non ABCD members are welcome to take part in the audit and will be given access to the on-line audit tool when they register for the audit.

Register to take part in the audit and access to the on-line tool
To register for the audit and be given access to the on-line tool on the ABCD website on N3 click here.

Northern Ireland and Worldwide
As Northern Ireland is not on N3, a non N3 version of the tool has been developed which can allow any country in the world to enrol at no cost and utilise the facilities. Any country, and centres in the country, may collect and analyse their own data which will then automatically become part of worldwide audit.  For more information click here.

Further information
Further enquiries may be made to the ABCD nationwide audits database administrator of the project, Melissa Cull

   Register for the exenatide qw audit: UK

Register for the exenatide qw audit: Northern Ireland and non-UK

Access the N3 on-line tool
(UK: you need to be on N3)

Access the worldwide on-line tool
(Northern Ireland and non-UK)

Exenatide QW audit objectives

Order preprinted data entry forms

Download first visit data entry form

Download follow up visit data entry form

How to analyse your data - video

Nationwide exenatide audit

Nationwide liraglutide audit

Papers, abstracts, presentations, posters from the audit

Further information- contact us

Main ABCD homepage


The ABCD nationwide exanatide QW audit is an independent audit supported by an unrestricted grant from Astra Zeneca

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